trilostane for dogs and cats


How do I know trilostane?

Trilostane is a synthetic steroidal enzyme inhibitor that decreases the high levels of cortisol hormone being produced by an overactive adrenal gland (hyperadrenocorticism).

How is trilostane given?

Trilostane is taken by mouth (by my mouth) in capsules. It is best to give it a long in conjunction with meals, and at the beginning of the day if you are doing daily dosing is required. This medication will take effect within one to two days.

Cleanse your hands after administering medication. If you’re pregnant or planning to get pregnant, avoid handling the medication. Don’t take the capsule out of the bottle and do not split the capsules.

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What if I miss giving my pet the medication or my package is not delivered on time?

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If you do not receive a dose, you can take the dose that you missed and administer it at the following scheduled time. Then, you can go back to your regular dosing schedule. Do not give your pet two doses at the same time or provide additional doses.

Do not stop taking this medication without consulting with your physician.

Are there any possible negative side consequences?

Trilostane is an antidepressant medication that is usually stopped working within 24 hours. It is easily tolerated. However, adverse reactions can include fatigue and vomiting, diarrhea and loss of appetite over the initial few days of treatment. The reduction of dosage and slowly increasing it until the prescribed dosage could help reduce side effects. Talk to your vet when your pet is experiencing the aforementioned signs. The side effects are usually minimal and go away by themselves.

Hypoadrenocorticism is a possibility and it is typically reversible after the medication has been stopped However, in uncommon cases adrenal gland damage and even death may occur in dogs.

For cats, these side effects can include anorexia, lethargy, and decreased mental stimulation.

A life-threatening situation referred to as an Addisonian crisis, could develop during the use of this drug. The pet must be watched closely for diarrhea, vomiting shaking, lethargy, or lethargy. excessive drinking or urination weakness, collapse, or weakness.

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Are any risk factors associated with this medicine?

Trilostane is not recommended in pets that are sensitive or have an allergy to it, or when pregnant or nursing animals. Trilostane is recommended to use cautiously in animals with liver or kidney impairment, or in nursing animals. The safety of the use of trilostane has not been tested in male dogs and cats being that are used to breed.

Are there any interactions with drugs that I must be conscious of?

Trilostane must be taken cautiously when combined in combination with any of the following medications: ACE inhibitors (such as benazepril and enalapril) aminoglutethimide ketoconazole, mitotane, and diuretics with potassium-sparing properties (spironolactone) and potassium supplements.

Make sure you inform your vet about all medication (including supplements, vitamins, or herbal treatments) your pet is taking.

Does there need to be any monitoring that must be conducted for this medication?

It is essential to watch your pet’s health closely for any negative effects. When you first start the medication, regular and frequent check-ups with your veterinarian are crucial. Adrenocorticotropic hormone (ACTH) stimulation tests as well as other lab tests are required to check for any adverse effects, effectiveness, and dosage adequacy.

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How can I conserve trilostane?

Trilostane capsules are best stored in sealed, light-resistant containers at a temperature of 25 degrees Celsius (77degF) and with short intervals between 15deg and 30degC (59deg – 85degF) are allowed.

How should I act in case of an emergency?

If you experience an Addisonian emergency, glucocorticoids must be administered immediately and then followed by veterinary treatment. Your vet should supply you with an immediate supply of glucocorticoids, as to protect you.

If you suspect you’ve had a drug overdose, or experiencing an allergic reaction from the medicine, contact your veterinarian’s office immediately. If they’re not available and you are not sure of their instructions, follow them when contacting an emergency clinic.

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Specific Precautions to Use Trilostane

Trilostane should only be administered to the pet as prescribed by the veterinarian. The medication must be kept away from the reach of pets and children.
Trilostane is to be taken with caution for pets who are nursing or pregnant as it could alter other hormones that are produced by the adrenal gland. This drug should be used with caution in dogs and cats suffering from dehydration, weakness, or abnormal serum electrolyte levels because it can block the synthesis of other hormones (mineralocorticoids).

Special precautions to be aware of when using Trilostane

Trilostane can only be given to the pet as prescribed by the veterinarian. The medication must be kept away from the reach of pets and children.
Trilostane should be administered with caution for pets who are nursing or pregnant because it can influence other hormones made by the adrenal gland. This drug should be used with caution in dogs suffering from dehydration, weakness, or abnormal serum electrolyte levels because it can block the synthesis of other hormones (mineralocorticoids).
Since trilostane’s metabolism is carried out by the liver, it must be avoided in pets who have kidney or liver issues. Trilostane is also recommended to be used with caution when pets are who are diagnosed with anemia.

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Uses trilostane vetoryl “cats and dogs”

trilostane vetoryl is used can be approved to treat pituitary-dependent hyperadrenocorticism, as well as the treatment of hyper, which is caused by adrenocortical tumors in dogs.

Dosage and Administration

Follow the dose directions from your doctor. trilostane vetoryl is best taken with food unless prescribed by your doctor.

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Didn’t Get Your Dose?

If you take a dose of Trilostane that is not taken, take it when you remember. If you can remember when you’re almost ready to take your next dose, you can skip the one you missed, and return to your normal routine. Don’t double the dose.

Possible side effects

  • The most commonly reported adverse reactions of Trilostane are:
  • Some of the more serious consequences can include:

Hypoadrenocorticism that is mild or asymptomatic, as well necrosis or rupture can occur and could cause death.
Stop immediately and consult your veterinarian if your dog is suffering from any health issues or adverse effects during the course of Trilostane.


Do not administer the medication to dogs who have an allergy to Trilostane. If your dog is experiencing a reaction to Trilostane that is allergic, consult your veterinarian immediately.

Avoid using Trilostane in pregnant dogs. Research has shown the effects of teratogenic drugs and early loss of pregnancy.

Do not give it to pets with primary liver disease or other kinds of kidney disease. Trilostane’s use could cause your dog to develop hypoadrenocorticism or corticosteroid withdrawal syndrome.

What is Cushing’s disease in dogs?

Cushing’s disease (hyperadrenocorticism) is a serious health condition in dogs that occurs when the adrenal glands overproduce cortisol (cortisone) in the animal’s body. The excess cortisol could make a dog more susceptible to a variety of serious ailments and ailments, ranging from kidney damage to diabetes and even life-threatening.


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