trilostane for dog and cat: Uses, Dosage & Side Effects

trilostane for dogs

How do I know trilostane?


Trilostane is a synthetic steroidal enzyme inhibitor that decreases the high levels of cortisol hormone produced by an overactive adrenal gland (hyperadrenocorticism).

How is trilostane given?


Trilostane is taken by mouth (by my mouth) in capsules. It is best to give it a long in conjunction with meals, and at the beginning of the day if you are doing daily dosing is required. This medication will take effect within one to two days.

Cleanse your hands after administering medication. If you’re pregnant or planning to get pregnant, avoid handling the medication. Don’t take the capsule out of the bottle and do not split the capsules.

READ MORE: Why do dogs have wet noses and cold as well as dry ones?

What if I miss giving my pet the medication or my package is not delivered on time?

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If you do not receive a dose, you can take the dose that you missed and administer it at the following scheduled time. Then, you can go back to your regular dosing schedule. Do not give your pet two doses at the same time or provide additional doses.

Do not stop taking this medication without consulting with your physician.

Are there any possible negative side consequences?


Trilostane is an antidepressant medication that is usually stopped working within 24 hours. It is easily tolerated. However, adverse reactions can include fatigue and vomiting, diarrhea, and loss of appetite over the initial few days of treatment. The reduction of dosage and slowly increasing it until the prescribed dosage could help reduce side effects. Talk to your vet when your pet is experiencing the aforementioned signs. The side effects are usually minimal and go away by themselves.

Hypoadrenocorticism is a possibility and it is typically reversible after the medication has been stopped However, in uncommon cases adrenal gland damage and even death may occur in dogs.

For cats, these side effects can include anorexia, lethargy, and decreased mental stimulation.

A life-threatening situation referred to as an Addisonian crisis, could develop during the use of this drug. The pet must be watched closely for diarrhea, vomiting shaking, lethargy, or lethargy. excessive drinking or urination weakness, collapse, or weakness.

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Are any risk factors associated with this medicine?


Trilostane is not recommended in pets that are sensitive or have an allergy to it, or when pregnant or nursing animals. Trilostane is recommended to use cautiously in animals with liver or kidney impairment, or in nursing animals. The safety of the use of trilostane has not been tested in male dogs and cats that are used to breed.

Are there any interactions with drugs that I must be conscious of?


Trilostane must be taken cautiously when combined in combination with any of the following medications: ACE inhibitors (such as benazepril and enalapril) aminoglutethimide ketoconazole, mitotane, and diuretics with potassium-sparing properties (spironolactone) and potassium supplements.

Make sure you inform your vet about all medication (including supplements, vitamins, or herbal treatments) your pet is taking.

Does there need to be any monitoring that must be conducted for this medication?


It is essential to watch your pet’s health closely for any negative effects. When you first start the medication, regular and frequent check-ups with your veterinarian are crucial. Adrenocorticotropic hormone (ACTH) stimulation tests as well as other lab tests are required to check for any adverse effects, effectiveness, and dosage adequacy.

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How can I conserve trilostane?


Trilostane capsules are best stored in sealed, light-resistant containers at a temperature of 25 degrees Celsius (77degF) and with short intervals between 15deg and 30degC (59deg – 85degF) are allowed.

How should I act in case of an emergency?


If you experience an Addisonian emergency, glucocorticoids must be administered immediately and then followed by veterinary treatment. Your vet should supply you with an immediate supply of glucocorticoids, as to protect you.

If you suspect you’ve had a drug overdose, or experiencing an allergic reaction to the medicine, contact your veterinarian’s office immediately. If they’re not available and you are not sure of their instructions, follow them when contacting an emergency clinic.

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Specific Precautions to Use Trilostane


Trilostane should only be administered to the pet as prescribed by the veterinarian. The medication must be kept away from the reach of pets and children.
Trilostane is to be taken with caution for pets who are nursing or pregnant as it could alter other hormones that are produced by the adrenal gland. This drug should be used with caution in dogs and cats suffering from dehydration, weakness, or abnormal serum electrolyte levels because it can block the synthesis of other hormones (mineralocorticoids).

Special precautions to be aware of when using Trilostane


Trilostane can only be given to the pet as prescribed by the veterinarian. The medication must be kept away from the reach of pets and children.
Trilostane should be administered with caution for pets who are nursing or pregnant because it can influence other hormones made by the adrenal gland. This drug should be used with caution in dogs suffering from dehydration, weakness, or abnormal serum electrolyte levels because it can block the synthesis of other hormones (mineralocorticoids).
Since trilostane’s metabolism is carried out by the liver, it must be avoided in pets who have kidney or liver issues. Trilostane is also recommended to be used with caution when pets are who are diagnosed with anemia.

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Uses trilostane vetoryl “cats and dogs”


trilostane vetoryl can be approved to treat pituitary-dependent hyperadrenocorticism, as well as the treatment of hyper, which is caused by adrenocortical tumors in dogs.

Dosage and Administration


Follow the dose directions from your doctor. trilostane vetoryl is best taken with food unless prescribed by your doctor.

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Didn’t Get Your Dose?


If you take a dose of Trilostane that is not taken, take it when you remember. If you can remember when you’re almost ready to take your next dose, you can skip the one you missed, and return to your normal routine. Don’t double the dose.

trilostane dosage for dogs

The dosage of trilostane for dogs varies based on the dog’s weight, condition, and the specific recommendations of a veterinarian. Trilostane is primarily used to treat Cushing’s disease (hyperadrenocorticism) in dogs, and the dosage will depend on the severity of the disease and the individual dog’s response to the medication.

Here are some general guidelines for trilostane dosage in dogs:

  1. Initial Dosage: The initial dosage of trilostane is usually determined by the veterinarian after evaluating the dog’s weight and condition. It’s important to start with a conservative dose to avoid sudden drops in cortisol levels.
  2. Titration: Trilostane dosage may need to be adjusted over time through a process called titration. This involves monitoring the dog’s clinical signs, cortisol levels, and any potential side effects. The goal is to find the lowest effective dose that manages the symptoms of Cushing’s disease without causing adverse effects.
  3. Dosage Frequency: Trilostane is typically given once or twice daily, as prescribed by the veterinarian. Some dogs may require daily dosing, while others might respond well to every other day dosing. The dosing frequency depends on the individual dog’s needs.
  4. Monitoring: Regular veterinary visits are crucial to monitor the dog’s response to trilostane. Blood tests to measure cortisol levels and assess liver function may be necessary during the treatment process.
  5. Follow Veterinarian’s Instructions: Always follow the dosage instructions provided by the veterinarian.
  6. Administering the Medication: Trilostane is available in tablet form and should be administered orally with food to help reduce the risk of gastrointestinal upset.
  7. Safety Precautions: Be aware of potential side effects and contact the veterinarian if any unusual symptoms or adverse reactions occur.

Keep in mind that trilostane dosages are individualized for each dog, and the information provided here is for general reference only. Only a veterinarian can determine the appropriate trilostane dosage based on a thorough assessment of the dog’s health and condition. If your dog has been diagnosed with Cushing’s disease and prescribed trilostane, it’s important to work closely with your veterinarian for proper dosing and monitoring.

Possible side effects

  • The most commonly reported adverse reactions of Trilostane are:
  • Some of the more serious consequences can include:


Hypoadrenocorticism that is mild or asymptomatic, as well as necrosis or rupture can occur and could cause death.
Stop immediately and consult your veterinarian if your dog is suffering from any health issues or adverse effects during the course of Trilostane.

Precautions


Do not administer the medication to dogs who have an allergy to Trilostane. If your dog is experiencing a reaction to Trilostane that is allergic, consult your veterinarian immediately.

Avoid using Trilostane in pregnant dogs. Research has shown the effects of teratogenic drugs and early loss of pregnancy.

Do not give it to pets with primary liver disease or other kinds of kidney disease. Trilostane’s use could cause your dog to develop hypoadrenocorticism or corticosteroid withdrawal syndrome.

What is Cushing’s disease in dogs?

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Cushing’s disease (hyperadrenocorticism) is a serious health condition in dogs that occurs when the adrenal glands overproduce cortisol (cortisone) in the animal’s body. The excess cortisol could make a dog more susceptible to a variety of serious ailments and ailments, ranging from kidney damage to diabetes and even life-threatening.

trilostane for dogs side effects

Trilostane is a medication commonly used in veterinary medicine to treat Cushing’s disease (hyperadrenocorticism) in dogs.

While it can be effective in managing the symptoms of this condition, it may also be associated with certain side effects.

It’s important to note that not all dogs will experience these side effects, and their severity can vary. If your dog is prescribed trilostane, closely monitor them for any adverse reactions and consult your veterinarian if you have concerns. Here are some potential trilostane side effects for dogs:

  1. Gastrointestinal Upset: Common side effects may include vomiting, diarrhea, and decreased appetite. Administering trilostane with food can help minimize gastrointestinal discomfort.
  2. Lethargy: Some dogs may experience increased lethargy or a decrease in activity levels. This can be temporary and might improve as the dog adjusts to the medication.
  3. Weakness or Collapse: In some cases, dogs might experience weakness, lethargy, or even collapse. This can be due to a rapid drop in cortisol levels. If this occurs, contact your veterinarian immediately.
  4. Changes in Water Consumption and Urination: Trilostane may lead to changes in a dog’s drinking and urination patterns. This can include increased thirst and urination.
  5. Changes in Behavior: Dogs on trilostane might exhibit changes in behavior, including increased restlessness or changes in mood.
  6. Electrolyte Imbalance: Trilostane can influence electrolyte balance in the body, which might lead to symptoms such as weakness, tremors, or even seizures.
  7. Skin and Coat Changes: Some dogs may experience changes in their skin or coat, such as thinning of the skin, hair loss, or changes in coat texture.
  8. Liver Enzyme Changes: Trilostane can affect liver enzymes, which might be monitored through blood tests.
  9. Hypoadrenocorticism (Addison ‘s-like Crisis): In rare cases, trilostane can lead to a sudden drop in cortisol levels, resulting in symptoms similar to Addison’s disease (hypoadrenocorticism). These symptoms can include vomiting, diarrhea, weakness, and collapse.
  10. Other Allergic Reactions: Dogs may potentially experience allergic reactions to the medication, which could include facial swelling, hives, or difficulty breathing.

It’s crucial to work closely with your veterinarian when your dog is prescribed trilostane. They can help you understand the potential side effects, monitor your dog’s health, and adjust the dosage if needed. If you notice any unusual or severe side effects, contact your veterinarian immediately for guidance.

trilostane side effects in humans

Trilostane is primarily used in veterinary medicine to treat Cushing’s disease in dogs and cats, and its use in humans is limited and not approved by regulatory authorities for human use. However, for informational purposes, here are some potential side effects of trilostane that have been observed in studies involving humans:

  1. Adrenal Insufficiency: Trilostane works by inhibiting cortisol production, which can lead to a reduction in cortisol levels. In some cases, this can result in adrenal insufficiency, a condition where the adrenal glands do not produce enough cortisol. Symptoms may include fatigue, weakness, low blood pressure, and electrolyte imbalances.
  2. Gastrointestinal Disturbances: Trilostane use can lead to gastrointestinal side effects, including nausea, vomiting, and diarrhea.
  3. Dizziness and Fatigue: Some individuals taking trilostane may experience dizziness or fatigue as a side effect.
  4. Skin Reactions: Skin reactions such as rash or itching have been reported in some cases.
  5. Liver Enzyme Changes: Trilostane can affect liver enzymes, which may be monitored through blood tests.
  6. Hormonal Imbalances: Trilostane can influence the balance of various hormones in the body, which might lead to hormonal imbalances.
  7. Interactions with Other Medications: Trilostane may interact with other medications, potentially affecting their efficacy or causing additional side effects.

It’s important to note that trilostane is not approved for human use and is not available for human consumption through regulated channels. Any use of trilostane in humans should only occur under the supervision and guidance of a qualified medical professional, and potential side effects should be discussed thoroughly.

If you suspect you are experiencing side effects from any medication, including trilostane, or if you have questions about its use, it’s crucial to consult a healthcare provider for appropriate advice and care.

FAQs: trilostane for dogs

What is Trilostane?

Trilostane is a medication used in veterinary medicine to treat hyperadrenocorticism, commonly known as Cushing’s disease, in both dogs and cats. Cushing’s disease is a hormonal disorder that occurs when the adrenal glands produce excessive amounts of cortisol.

What are the common uses for Trilostane?

Trilostane is primarily used to treat Cushing’s disease in dogs and cats. It helps to reduce the excessive production of cortisol, alleviating the symptoms associated with the disease, such as excessive thirst, hunger, and urination.

How is Trilostane administered?

Trilostane is available in tablet form and is typically administered orally to dogs and cats. The dosage and administration schedule will be determined by a veterinarian based on the animal’s weight, condition, and response to treatment.

What are the potential side effects of Trilostane?

Common side effects of Trilostane may include lethargy, vomiting, diarrhea, loss of appetite, and changes in water intake and urination. More serious side effects can include weakness, collapse, or changes in behavior.

How should Trilostane be given to pets?

Follow the veterinarian’s instructions for administering Trilostane. It’s important to give the medication at the same time each day and with food to reduce the risk of stomach upset. Never adjust the dosage or frequency without consulting a veterinarian.

Is Trilostane safe for long-term use?

Trilostane can be used as a long-term treatment for managing Cushing’s disease in pets. Regular veterinary check-ups are essential to monitor the pet’s health and adjust the dosage as needed.

Can Trilostane be used in pregnant or lactating animals?

Trilostane is generally not recommended for use in pregnant or lactating animals, as its safety during these conditions has not been thoroughly studied. Consult a veterinarian for guidance if needed.

Can Trilostane interact with other medications?

Trilostane has the potential to interact with other medications, including certain drugs used to treat heart conditions, antifungal medications, and other hormonal medications. Always inform your veterinarian about all medications and supplements your pet is taking.

What should I do if I miss a dose of Trilostane?

If a dose is missed, follow the veterinarian’s instructions. Do not give a double dose to make up for the missed one. Contact the veterinarian if you have questions about missed doses.

Please note that this information is provided as a general overview and should not replace professional veterinary advice. If your pet requires medical treatment or medication, consult a veterinarian for accurate guidance tailored to your pet’s specific needs.